Direct oral anticoagulants and venous malformations: literature review and retrospective study of 29 patients.

ABSTRACT:

Background

Venous malformations (VMs) are commonly associated with localized intravascular coagulopathy leading to elevated D-dimer and risks of hemorrhagic and thromboembolic events, particularly in extensive lesions. While low-molecular-weight heparin (LMWH) has been effective in managing coagulopathy and pain, direct oral anticoagulants (DOACs) emerge as a promising alternative.

Objectives

This study aims to evaluate the efficacy and safety of DOACs in treating VMs associated with localized intravascular coagulopathy, offering a comparative perspective to LMWH.

Methods

A retrospective study was conducted on 29 patients with VMs and secondary localized intravascular coagulopathy treated with DOACs between 2013 and 2023 in a single tertiary center specialized in vasc

SUBMITTER: Lagneaux E 

PROVIDER: S-EPMC11087699 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature