Evolution of invasive pneumococcal disease by serotype 3 in adults: a Spanish three-decade retrospective study.

ABSTRACT:

Background

Invasive pneumococcal disease due to serotype 3 (S3-IPD) is associated with high mortality rates and long-term adverse effects. The introduction of the 13-valent pneumococcal conjugate vaccine (PCV13) into the Spanish paediatric immunisation programme has not led to a decrease in the adult S3-IPD. We aimed to analyse the incidence, clinical characteristics and genomics of S3-IPD in adults in Spain.

Methods

Adult IPD episodes hospitalized in a Southern Barcelona hospital were prospectively collected (1994-2020). For genomic comparison, S3-IPD isolates from six Spanish hospitals (2008-2020) and historical isolates (1989-1993) were analysed by WGS (Illumina and/or MinION).

Findings

From 1994 to 2020, 270 S3-IPD episodes were detected. When comparing pre-PCV (1

SUBMITTER: Calvo-Silveria S 

PROVIDER: S-EPMC11087702 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature