Neuronal innervation regulates the secretion of neurotrophic myokines and exosomes from skeletal muscle.

ABSTRACT: Myokines and exosomes, originating from skeletal muscle, are shown to play a significant role in maintaining brain homeostasis. While exercise has been reported to promote muscle secretion, little is known about the effects of neuronal innervation and activity on the yield and molecular composition of biologically active molecules from muscle. As neuromuscular diseases and disabilities associated with denervation impact muscle metabolism, we hypothesize that neuronal innervation and firing may play a pivotal role in regulating secretion activities of skeletal muscles. We examined this hypothesis using an engineered neuromuscular tissue model consisting of skeletal muscles innervated by motor neurons. The innervated muscles displayed elevated expression of mRNAs encoding neurotrophic myokin

SUBMITTER: Huang KY 

PROVIDER: S-EPMC11087749 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature