Effect of immediate initiation of invasive ventilation on mortality in acute hypoxemic respiratory failure: a target trial emulation.

ABSTRACT:

Purpose

Invasive ventilation is a fundamental treatment in intensive care but its precise timing is difficult to determine. This study aims at assessing the effect of initiating invasive ventilation versus waiting, in patients with hypoxemic respiratory failure without immediate reason for intubation on one-year mortality.

Methods

Emulation of a target trial to estimate the benefit of immediately initiating invasive ventilation in hypoxemic respiratory failure, versus waiting, among patients within the first 48-h of hypoxemia. The eligible population included non-intubated patients with SpO₂/FiO₂ ≤ 200 and SpO₂ ≤ 97%. The target trial was emulated using a single-center database (MIMIC-IV) which contains granular information about clinical sta

SUBMITTER: Mellado-Artigas R 

PROVIDER: S-EPMC11088053 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature