Comparison of limited driving pressure ventilation and low tidal volume strategies in adults with acute respiratory failure on mechanical ventilation: a randomized controlled trial.

ABSTRACT:

Background

Ventilator-induced lung injury (VILI) presents a grave risk to acute respiratory failure patients undergoing mechanical ventilation. Low tidal volume (LTV) ventilation has been advocated as a protective strategy against VILI. However, the effectiveness of limited driving pressure (plateau pressure minus positive end-expiratory pressure) remains unclear.

Objectives

This study evaluated the efficacy of LTV against limited driving pressure in preventing VILI in adults with respiratory failure.

Design

A single-centre, prospective, open-labelled, randomized controlled trial.

Methods

This study was executed in medical intensive care units at Siriraj Hospital, Mahidol University, Bangkok, Thailand. We enrolled acute respiratory failure patients undergoing i

SUBMITTER: Tongyoo S 

PROVIDER: S-EPMC11088295 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature