Examining the validity of the addictions neuroclinical assessment domains in a crowdsourced sample of adults with current alcohol use.

ABSTRACT: Several dimensional frameworks for characterizing heterogeneity in alcohol use disorder (AUD) have been proposed, including the Addictions Neuroclinical Assessment (ANA). The ANA is a framework for assessing individual variability within AUD across three domains corresponding to the proposed stages of the addiction cycle: reward (binge-intoxication stage), negative emotionality (withdrawal-negative affect stage), and cognitive control (preoccupation-anticipation stage). Recent work has evaluated the ANA's three-factor structure and construct validity, primarily in treatment-seekers with AUD. We extended this research by examining the factor structure, bias across alcohol use severity, longitudinal invariance, and concurrent and predictive validity of a novel assessment of the ANA domains i

SUBMITTER: Votaw VR 

PROVIDER: S-EPMC11088344 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature