Modification of coronary artery disease clinical risk factors by coronary artery disease polygenic risk score.

ABSTRACT:

Background

The extent to which the relationships between clinical risk factors and coronary artery disease (CAD) are altered by CAD polygenic risk score (PRS) is not well understood. Here, we determine whether the interactions between clinical risk factors and CAD PRS further explain risk for incident CAD.

Methods

Participants were of European ancestry from the UK Biobank without prevalent CAD. An externally trained genome-wide CAD PRS was generated and then applied. Clinical risk factors were ascertained at baseline. Cox proportional hazards models were fitted to examine the incident CAD effects of CAD PRS, risk factors, and their interactions. Next, the PRS and risk factors were stratified to investigate the attributable risk of clinical risk factors.

Findings

A tot

SUBMITTER: Truong B 

PROVIDER: S-EPMC11088498 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature