Genetic and transcriptomic landscape of colonic diverticulosis.

ABSTRACT:

Objective

Colonic diverticulosis is a prevalent condition among older adults, marked by the presence of thin-walled pockets in the colon wall that can become inflamed, infected, haemorrhage or rupture. We present a case-control genetic and transcriptomic study aimed at identifying the genetic and cellular determinants underlying this condition and the relationship with other gastrointestinal disorders.

Design

We conducted DNA and RNA sequencing on colonic tissue from 404 patients with (N=172) and without (N=232) diverticulosis. We investigated variation in the transcriptome associated with diverticulosis and further integrated this variation with single-cell RNA-seq data from the human intestine. We also integrated our expression quantitative trait loci with genome-wide asso

SUBMITTER: Seo J 

PROVIDER: S-EPMC11088512 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature