A mucus production programme promotes classical pancreatic ductal adenocarcinoma.

ABSTRACT:

Objective

The optimal therapeutic response in cancer patients is highly dependent upon the differentiation state of their tumours. Pancreatic ductal adenocarcinoma (PDA) is a lethal cancer that harbours distinct phenotypic subtypes with preferential sensitivities to standard therapies. This study aimed to investigate intratumour heterogeneity and plasticity of cancer cell states in PDA in order to reveal cell state-specific regulators.

Design

We analysed single-cell expression profiling of mouse PDAs, revealing intratumour heterogeneity and cell plasticity and identified pathways activated in the different cell states. We performed comparative analysis of murine and human expression states and confirmed their phenotypic diversity in specimens by immunolabeling. We assessed t

SUBMITTER: Tonelli C 

PROVIDER: S-EPMC11088527 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature