RNA Post-transcriptional Modifications of an Early-Stage Large-Subunit Ribosomal Intermediate.

ABSTRACT: Protein production by ribosomes is fundamental to life, and proper assembly of the ribosome is required for protein production. The RNA, which is post-transcriptionally modified, provides the platform for ribosome assembly. Thus, a complete understanding of ribosome assembly requires the determination of the RNA post-transcriptional modifications in all of the ribosome assembly intermediates and on each pathway. There are 26 RNA post-transcriptional modifications in 23S RNA of the mature Escherichia coli (E. coli) large ribosomal subunit. The levels of these modifications have been investigated extensively only for a small number of large subunit intermediates and under a limited number of cellular and environmental conditions. In this study, we determined the level of incorp

SUBMITTER: Narayan G 

PROVIDER: S-EPMC11088935 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature