Exploring causal correlations between inflammatory cytokines and Meniere's disease: a Mendelian randomization.

ABSTRACT:

Objectives

Previous studies have highlighted associations between certain inflammatory cytokines and Ménière's Disease (MD), such as interleukin (IL) -13 and IL-1β. This Mendelian randomization aims to comprehensively evaluate the causal relationships between 91 inflammatory cytokines and MD.

Methods

A comprehensive two-sample Mendelian randomization (MR) analysis was conducted to determine the causal association between inflammatory cytokines and MD. Utilizing publicly accessible genetic datasets, we explored causal links between 91 inflammatory cytokines and MD risk. Comprehensive sensitivity analyses were employed to assess the robustness, heterogeneity, and presence of horizontal pleiotropy in our findings.

Results

Our findings indicate that MD causally influences

SUBMITTER: Xie S 

PROVIDER: S-EPMC11089180 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature