Single-cell transcriptomics reveals a role for pancreatic duct cells as potential mediators of inflammation in diabetes mellitus.

ABSTRACT:

Introduction

Inflammation of the pancreas contributes to the development of diabetes mellitus. Although it is well-accepted that local inflammation leads to a progressive loss of functional beta cell mass that eventually causes the onset of the disease, the development of islet inflammation remains unclear.

Methods

Here, we used single-cell RNA sequencing to explore the cell type-specific molecular response of primary human pancreatic cells exposed to an inflammatory environment.

Results

We identified a duct subpopulation presenting a unique proinflammatory signature among all pancreatic cell types.

Discussion

Overall, the findings of this study point towards a role for duct cells in the propagation of islet inflammation, and in immune cell recruitment and acti

SUBMITTER: Munoz Garcia A 

PROVIDER: S-EPMC11089191 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature