Ultrasmall copper nanoclusters as an efficient antibacterial agent for primary peritonitis therapy.

ABSTRACT: The urgent need to develop biocompatible, non-resistant antibacterial agents to effectively combat Gram-negative bacterial infections, particularly for the treatment of peritonitis, presents a significant challenge. In this study, we introduce our water-soluble Cu₃₀ nanoclusters (NCs) as a potent and versatile antibacterial agent tailored for addressing peritonitis. The as-synthesized atomically precise Cu₃₀ NCs demonstrate exceptional broad-spectrum antibacterial performance, and especially outstanding bactericidal activity of 100% against Gram-negative Escherichia coli (E. coli). Our in vivo experimental findings indicate that the Cu₃₀ NCs exhibit remarkable therapeutic efficacy against primary peritonitis caused by E. coli inf

SUBMITTER: Wang Y 

PROVIDER: S-EPMC11089525 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature