Synthesis and Monoamine Oxidase Inhibitory Activity of Halogenated Flavones.

ABSTRACT: Small molecule neurotransmitters containing amines are metabolized by monoamine oxidase (MAO) in the nervous system. Monoamine oxidase inhibitors are a valuable class of drugs prescribed for the management of neurological disorders, including depression. A series of halogenated flavonoids similar to the dietary flavonoid acacetin were designed as selective MAO-B inhibitors. MAO-A and -B inhibition of 36 halogenated flavones were tested. The halogens (fluorine and chlorine) were placed at positions 5 and 7 on ring A of the flavone scaffold. All compounds were selective MAO-B inhibitors with micro- and nanomolar IC₅₀ values. Compounds 9f, 10a-c, 11a-c, 11g,h, and 11l displayed inhibitory activity toward MAO-B with IC_50</

SUBMITTER: Castillo-Arellano JI 

PROVIDER: S-EPMC11089559 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature