A single amino acid change in the murine leukemia virus capsid gene responsible for the Fv1(nr) phenotype.

ABSTRACT: The nr allele at the mouse Fv1 restriction locus governs resistance to B-tropic and some N-tropic murine leukemia viruses (MLVs). Sequence analysis and site-specific mutagenesis of N-tropic MLVs identified a single amino acid difference responsible for this restriction that is distinct from the site that governs N or B tropism. Viruses with other substitutions at this site were evaluated for altered replication patterns.

SUBMITTER: Jung YT 

PROVIDER: S-EPMC110898 | biostudies-literature | 2000 Jun

REPOSITORIES: biostudies-literature