Gut microbial metabolism is linked to variations in circulating non-high density lipoprotein cholesterol.

ABSTRACT:

Background

Non-high-density lipoprotein cholesterol (non-HDL-c) was a strong risk factor for incident cardiovascular diseases and proved to be a better target of lipid-lowering therapies. Recently, gut microbiota has been implicated in the regulation of host metabolism. However, its causal role in the variation of non-HDL-c remains unclear.

Methods

Microbial species and metabolic capacities were assessed with fecal metagenomics, and their associations with non-HDL-c were evaluated by Spearman correlation, followed by LASSO and linear regression adjusted for established cardiovascular risk factors. Moreover, integrative analysis with plasma metabolomics were performed to determine the key molecules linking microbial metabolism and variation of non-HDL-c. Furthermore, bi-direc

SUBMITTER: Zhou S 

PROVIDER: S-EPMC11090025 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature