Contribution of mechanoreceptors to spinal cord injury-induced mechanical allodynia.

ABSTRACT:

Abstract

Evidence from previous studies supports the concept that spinal cord injury (SCI)-induced neuropathic pain (NP) has its neural roots in the peripheral nervous system. There is uncertainty about how and to which degree mechanoreceptors contribute. Sensorimotor activation-based interventions (eg, treadmill training) have been shown to reduce NP after experimental SCI, suggesting transmission of pain-alleviating signals through mechanoreceptors. The aim of the present study was to understand the contribution of mechanoreceptors with respect to mechanical allodynia in a moderate mouse contusion SCI model. After genetic ablation of tropomyosin receptor kinase B expressing mechanoreceptors before SCI, mechanical allodynia was reduced. The identical genetic ablation after SCI did

SUBMITTER: Sliwinski C 

PROVIDER: S-EPMC11090032 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature