Palladium-Catalyzed Carbonylative Difunctionalization of Unactivated Alkenes Initiated by Unstabilized Enolates.

ABSTRACT: This report describes the first example of palladium-catalyzed carbonylative difunctionalization of unactivated alkenes initiated by enolate nucleophiles. The approach involves initiation by an unstabilized enolate nucleophile under an atmospheric pressure of CO and termination with a carbon electrophile. This process is compatible with a diverse range of electrophiles, including aryl, heteroaryl, and vinyl iodides to yield synthetically useful 1,5-diketone products, which were demonstrated to be precursors for multi-substituted pyridines. A Pd^I -dimer complex with two bridging CO units was observed although its role in catalysis is not yet understood.

SUBMITTER: Zhang P 

PROVIDER: S-EPMC11090370 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature