The fitness consequences of genetic divergence between polymorphic gene arrangements.

ABSTRACT: Inversions restrict recombination when heterozygous with standard arrangements, but often have few noticeable phenotypic effects. Nevertheless, there are several examples of inversions that can be maintained polymorphic by strong selection under laboratory conditions. A long-standing model for the source of such selection is divergence between arrangements with respect to recessive or partially recessive deleterious mutations, resulting in a selective advantage to heterokaryotypic individuals over homokaryotypes. This paper uses a combination of analytical and numerical methods to investigate this model, for the simple case of an autosomal inversion with multiple independent nucleotide sites subject to mildly deleterious mutations. A complete lack of recombination in heterokaryotypes is as

SUBMITTER: Charlesworth B 

PROVIDER: S-EPMC11090464 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature