Protocol and Statistical Analysis Plan for the Mode of Ventilation During Critical Illness (MODE) Trial.

ABSTRACT:

Background

For every critically ill adult receiving invasive mechanical ventilation, clinicians must select a mode of ventilation. The mode of ventilation determines whether the ventilator directly controls the tidal volume or the inspiratory pressure. Newer hybrid modes allow clinicians to set a target tidal volume; the ventilator controls and adjusts the inspiratory pressure. A strategy of low tidal volumes and low plateau pressure improves outcomes, but the optimal mode to achieve these targets is not known.

Research question

Can a cluster-randomized trial design be used to assess whether the mode of mandatory ventilation affects the number of days alive and free of invasive mechanical ventilation among critically ill adults?

Study design and methods

The Mode of Ve

SUBMITTER: Seitz KP 

PROVIDER: S-EPMC11090486 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature