Racial disparities in colorectal cancer clinicopathological and molecular tumor characteristics: a systematic review.

ABSTRACT:

Purpose

African Americans have the highest colorectal cancer (CRC) mortality of all racial groups in the USA, which may relate to differences in healthcare access or advanced stage at diagnosis. Recent evidence indicates that differences in tumor characteristics may also underlie disparities in mortality. To highlight recent findings and areas for investigation, we completed the first systematic review of racial disparities in CRC tumor prognostic markers, including clinicopathological markers, microsatellite instability (MSI), oncogene mutations, and novel markers, including cancer stem cells and immune markers.

Methods

Relevant studies were identified via PubMed, limited to original research published within the last 10 years. Ninety-six articles were identified that compa

SUBMITTER: Lawler T 

PROVIDER: S-EPMC11090693 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature