Balancing fracture risk versus risk of mortality before fracture among women aged 80 years or older.

ABSTRACT:

Background

Most fractures occur in women aged ≥80 years but competing mortality unrelated to fracture may limit the benefit of osteoporosis drug therapy for some women in late life. Our primary aim was to develop separate prediction models for non-spine fracture (NSF) and mortality before fracture to identify subsets of women with varying fracture versus mortality risks.

Methods

Separate prediction models were developed for NSF and mortality before NSF for 4895 women aged ≥80 years enrolled in the Study of Osteoporotic Fractures (SOF) or the Health Aging and Body Composition (HABC) study. Proportional hazards models modified to account for competing mortality were used to identify candidate risk factors for each outcome. Predictors associated with NSF or mortality (p < 0.2)

SUBMITTER: Schousboe JT 

PROVIDER: S-EPMC11090747 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature