The leukemia inhibitory factor regulates fibroblast growth factor receptor 4 transcription in gastric cancer.

ABSTRACT:

Purpose

The gastric adenocarcinoma (GC) represents the third cause of cancer-related mortality worldwide, and available therapeutic options remain sub-optimal. The Fibroblast growth factor receptors (FGFRs) are oncogenic transmembrane tyrosine kinase receptors. FGFR inhibitors have been approved for the treatment of various cancers and a STAT3-dependent regulation of FGFR4 has been documented in the H.pylori infected intestinal GC. Therefore, the modulation of FGFR4 might be useful for the treatment of GC.

Methods

To investigate wich factors could modulate FGFR4 signalling in GC, we employed RNA-seq analysis on GC patients biopsies, human patients derived organoids (PDOs) and cancer cell lines.

Results

We report that FGFR4 expression/function is regulated by the leuke

SUBMITTER: Di Giorgio C 

PROVIDER: S-EPMC11090936 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature