Diagnosing and staging epithelial ovarian cancer by serum glycoproteomic profiling.

ABSTRACT:

Background

There is a need for diagnostic tests for screening, triaging and staging of epithelial ovarian cancer (EOC). Glycoproteomics of blood samples has shown promise for biomarker discovery.

Methods

We applied glycoproteomics to serum of people with EOC or benign pelvic masses and healthy controls. A total of 653 analytes were quantified and assessed in multivariable models, which were tested in an independent cohort. Additionally, we analyzed glycosylation patterns in serum markers and in tissues.

Results

We identified a biomarker panel that distinguished benign lesions from EOC with sensitivity and specificity of 83.5% and 90.1% in the training set, and of 86.7 and 86.7% in the test set, respectively. ROC analysis demonstrated strong performance across a range

SUBMITTER: Dhar C 

PROVIDER: S-EPMC11091186 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature