The causal effects of genetically determined immune cells on gynecologic malignancies: a Mendelian randomization study.

ABSTRACT:

Background

Evidence from observational studies suggested a connection between immune cells and gynecologic malignancies. To investigate potential causative associations between immunophenotype traits and gynecologic malignancies, we used a two-sample Mendelian randomization analysis.

Methods

The genetic instrumental variables of 731 immunophenotypes of peripheral blood were obtained by the GWAS database; the GWAS data of common gynecologic cancers were obtained from FinnGen study. The main statistic method was the inverse-variance weighted method. We also used the weighted mode, weighted median, and MR Egger for evaluations. The MR Steiger directionality test was further used to ascertain the reverse causal relationship between immune cells and gynecologic cancers.

Result

SUBMITTER: Li Y 

PROVIDER: S-EPMC11091348 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature