Reduction in Constitutively Activated Auditory Brainstem Microglia in Aging and Alzheimer's Disease.

ABSTRACT:

Background

Alzheimer's disease (AD) pathology is considered to begin in the brainstem, and cerebral microglia are known to play a critical role in AD pathogenesis, yet little is known about brainstem microglia in AD. Translocator protein (TSPO) PET, sensitive to activated microglia, shows high signal in dorsal brainstem in humans, but the precise location and clinical correlates of this signal are unknown.

Objective

To define age and AD associations of brainstem TSPO PET signal in humans.

Methods

We applied new probabilistic maps of brainstem nuclei to quantify PET-measured TSPO expression over the whole brain including brainstem in 71 subjects (43 controls scanned using 11C-PK11195; 20 controls and 8 AD subjects scanned using 11C-PBR28). We focused on inferior collic

SUBMITTER: Butler T 

PROVIDER: S-EPMC11091576 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature