Investigating the Shared Genetic Etiology Between Parkinson's Disease and Depression.

ABSTRACT:

Background

Depression is a common symptom in Parkinson's disease (PD), resulting from underlying neuropathological processes and psychological factors. However, the extent to which shared genetic risk factors contribute to the relationship between depression and PD is poorly understood.

Objective

To examine the effects of common genetic variants influencing the etiology of PD and depression risk at the genome-wide and local genomic regional level.

Methods

We comprehensively investigated the genetic relationship between PD and depression using genome-wide association studies data. First, we estimated the genetic correlation at the genome-wide level using linkage-disequilibrium score regression, followed by local genetic correlation analysis using the GWAS-pairwise meth

SUBMITTER: Reyes-Perez P 

PROVIDER: S-EPMC11091633 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature