Predictors of Loss of Ambulation in Duchenne Muscular Dystrophy: A Systematic Review and Meta-Analysis.

ABSTRACT:

Objective

The objective of this study was to describe predictors of loss of ambulation in Duchenne muscular dystrophy (DMD).

Methods

This systematic review and meta-analysis included searches of MEDLINE ALL, Embase, and the Cochrane Database of Systematic Reviews from January 1, 2000, to December 31, 2022, for predictors of loss of ambulation in DMD. Search terms included "Duchenne muscular dystrophy" as a Medical Subject Heading or free text term, in combination with variations of the term "predictor". Risk of bias was assessed using the Newcastle-Ottawa Scale. We performed meta-analysis pooling of hazard ratios of the effects of glucocorticoids (vs. no glucocorticoid therapy) by fitting a common-effect inverse-variance model.

Results

The bibliographic searches resul

SUBMITTER: Landfeldt E 

PROVIDER: S-EPMC11091649 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature