Rapidly achieving clinical remission in ulcerative colitis indicates better endoscopic and histological outcomes.

ABSTRACT:

Background

Clinical remission (CR) is the principal short-term treatment target in patients with ulcerative colitis (UC). However, whether rapidly achieving CR indicates better outcomes remains unclear.

Objectives

We aimed to explore the associations between the timing of CR and therapeutic outcomes in UC.

Methods

This study included UC patients from the UNIFI trial. Week-2 CR and time to CR were the major variables of interest. Endoscopic remission (ER) at week 52 was the primary outcome. Multivariate logistic regression was performed to evaluate the association between variables and outcomes.

Results

Week-2 CR was associated with ER (aOR: 2.37 [95% CI: 1.28, 4.37], p = 0.006) and Histological remission (HR) (aOR: 2.87 [95% CI: 1.42, 5.72], p = 0.003) at week

SUBMITTER: Chen R 

PROVIDER: S-EPMC11091780 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature