Innovation of 6-sulfonamide-2H-chromene derivatives as antidiabetic agents targeting α-amylase, α-glycosidase, and PPAR-γ inhibitors with in silico molecular docking simulation.

ABSTRACT: A new series of 2-imino or 2-oxo-2H-chromene-6-sulfonamide derivatives 2-9 with potential anti-diabetic activity were designed and synthesized. The new 6-sulfonamide chromenes were synthesized by reacting 3-formyl-4-hydroxybenzenesulfonyl chloride with activated methylene derivatives in the presence of ammonium acetate as a catalyst. The structure of the products was confirmed by spectroscopic analysis. All the designed derivatives 2-9 were evaluated for their activity against α-amylase and exhibited inhibitory percentage values higher than 93% at 100 μg mL^-1. Additionally, the IC₅₀ values represented a variable degree of activity with two derivatives 2 and 9 exhibiting the most promising derivative results with IC₅₀ values of 1.76 ± 0.01 and 1.08 ±

SUBMITTER: Thabet HK 

PROVIDER: S-EPMC11091863 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature