Investigating the causal relationship of gut microbiota with GERD and BE: a bidirectional mendelian randomization.

ABSTRACT:

Background

Gut microbiota(GM) have been proven associated with lots of gastrointestinal diseases, but its causal relationship with Gastroesophageal reflux disease(GERD) and Barrett's esophagus(BE) hasn't been explored. We aimed to uncover the causal relation between GM and GERD/BE and potential mediators by utilizing Mendelian Randomization(MR) analysis.

Methods

Summary statistics of GM(comprising 301 bacteria taxa and 205 metabolism pathways) were extracted from MiBioGen Consortium(N = 18,340) and Dutch Microbiome Project(N = 7,738), GERD and BE from a multitrait meta-analysis(N_GERD=602,604, N_BE=56,429). Bidirectional two-sample MR analysis and linkage disequilibrium score regression(LDSC) were used to explore the genetic correlation between GM and GER

SUBMITTER: Liu Y 

PROVIDER: S-EPMC11092028 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature