Dietary fibre supplementation enhances radiotherapy tumour control and alleviates intestinal radiation toxicity.

ABSTRACT:

Background

Non-toxic approaches to enhance radiotherapy outcomes are beneficial, particularly in ageing populations. Based on preclinical findings showing that high-fibre diets sensitised bladder tumours to irradiation by modifying the gut microbiota, along with clinical evidence of prebiotics enhancing anti-cancer immunity, we hypothesised that dietary fibre and its gut microbiota modification can radiosensitise tumours via secretion of metabolites and/or immunomodulation. We investigated the efficacy of high-fibre diets combined with irradiation in immunoproficient C57BL/6 mice bearing bladder cancer flank allografts.

Result

Psyllium plus inulin significantly decreased tumour size and delayed tumour growth following irradiation compared to 0.2% cellulose and raised intratu

SUBMITTER: Then CK 

PROVIDER: S-EPMC11092108 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature