Western diet increases brain metabolism and adaptive immune responses in a mouse model of amyloidosis.

ABSTRACT: Diet-induced increase in body weight is a growing health concern worldwide. Often accompanied by a low-grade metabolic inflammation that changes systemic functions, diet-induced alterations may contribute to neurodegenerative disorder progression as well. This study aims to non-invasively investigate diet-induced metabolic and inflammatory effects in the brain of an APPPS1 mouse model of Alzheimer's disease. [¹⁸F]FDG, [¹⁸F]FTHA, and [¹⁸F]GE-180 were used for in vivo PET imaging in wild-type and APPPS1 mice. Ex vivo flow cytometry and histology in brains complemented the in vivo findings. ¹H- magnetic resonance spectroscopy in the liver, plasma metabolomics and flow cytometry of the white adipose tissue were used to confirm metaflammatory conditio

SUBMITTER: Poxleitner M 

PROVIDER: S-EPMC11092112 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature