Ecology shapes the genomic and biosynthetic diversification of Streptomyces bacteria from insectivorous bats.

ABSTRACT: Streptomyces are prolific producers of secondary metabolites from which many clinically useful compounds have been derived. They inhabit diverse habitats but have rarely been reported in vertebrates. Here, we aim to determine to what extent the ecological source (bat host species and cave sites) influence the genomic and biosynthetic diversity of Streptomyces bacteria. We analysed draft genomes of 132 Streptomyces isolates sampled from 11 species of insectivorous bats from six cave sites in Arizona and New Mexico, USA. We delineated 55 species based on the genome-wide average nucleotide identity and core genome phylogenetic tree. Streptomyces isolates that colonize the same bat species or inhabit the same site exhibit greater overall genomic similarity than they

SUBMITTER: Montoya-Giraldo M 

PROVIDER: S-EPMC11092124 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature