Indirect CD4⁺ T cell protection against mouse gamma-herpesvirus infection via interferon gamma.

ABSTRACT: CD4⁺ T cells play a key role in γ-herpesvirus infection control. However, the mechanisms involved are unclear. Murine herpesvirus type 4 (MuHV-4) allows relevant immune pathways to be dissected experimentally in mice. In the lungs, it colonizes myeloid cells, which can express MHC class II (MHCII), and type 1 alveolar epithelial cells (AEC1), which lack it. Nevertheless, CD4⁺ T cells can control AEC1 infection, and this control depends on MHCII expression in myeloid cells. Interferon-gamma (IFNγ) is a major component of CD4⁺ T cell-dependent MuHV-4 control. Here, we show that the action of IFNγ is also indirect, as CD4⁺ T cell-mediated control of AEC1 infection depended on IFNγ receptor (IFNγR1) expression in CD11c⁺ cells. Indirect con

SUBMITTER: Xie W 

PROVIDER: S-EPMC11092340 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature