Regulation of ubiquitination and antiviral activity of Cactin by deubiquitinase Usp14 in Drosophila.

ABSTRACT: Cactin, a highly conserved protein, plays a crucial role in various physiological processes in eukaryotes, including innate immunity. Recently, the function of Cactin in the innate immunity of Drosophila has been explored, revealing that Cactin regulates a non-canonical signaling pathway associated with the Toll and Imd pathways via the Cactin-Deaf1 axis. In addition, Cactin exhibits specific antiviral activity against the Drosophila C virus (DCV) in Drosophila, with an unknown mechanism. During DCV infection, it has been confirmed that the protein level and antiviral activity of Cactin are regulated by ubiquitination. However, the precise ubiquitination and deubiquitination mechanisms of Cactin in Drosophila remain unexplored. In this study, we identifie

SUBMITTER: Rong Q 

PROVIDER: S-EPMC11092352 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature