Secreted phospholipase PLA2G2E contributes to regulation of T cell immune response against influenza virus infection.

ABSTRACT: The involvement of secreted phospholipase A2s in respiratory diseases, such as asthma and respiratory viral infections, is well-established. However, the specific role of secreted phospholipase A2 group IIE (PLA2G2E) during influenza virus infection remains unexplored. Here, we investigated the role of PLA2G2E during H1N1 influenza virus infection using a targeted mouse model lacking Pla2g2e gene (Pla2g2e^-/-). Our findings demonstrated that Pla2g2e^-/- mice had significantly lower survival rates and higher viral loads in lungs compared to wild-type mice following influenza virus infection. While Pla2g2e^-/- mice displayed comparable innate and humoral immune responses to influenza virus challenge, the animals showed impaired influe

SUBMITTER: Bu H 

PROVIDER: S-EPMC11092358 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature