Altered asymmetry of functional connectome gradients in major depressive disorder.

ABSTRACT:

Introduction

Major depressive disorder (MDD) is a debilitating disease involving sensory and higher-order cognitive dysfunction. Previous work has shown altered asymmetry in MDD, including abnormal lateralized activation and disrupted hemispheric connectivity. However, it remains unclear whether and how MDD affects functional asymmetries in the context of intrinsic hierarchical organization.

Methods

Here, we evaluate intra- and inter-hemispheric asymmetries of the first three functional gradients, characterizing unimodal-transmodal, visual-somatosensory, and somatomotor/default mode-multiple demand hierarchies, to study MDD-related alterations in overarching system-level architecture.

Results

We find that, relative to the healthy controls, MDD patients exhibit alterat

SUBMITTER: Yang Y 

PROVIDER: S-EPMC11092381 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature