Addressing pandemic-wide systematic errors in the SARS-CoV-2 phylogeny.

ABSTRACT: The SARS-CoV-2 genome occupies a unique place in infection biology - it is the most highly sequenced genome on earth (making up over 20% of public sequencing datasets) with fine scale information on sampling date and geography, and has been subject to unprecedented intense analysis. As a result, these phylogenetic data are an incredibly valuable resource for science and public health. However, the vast majority of the data was sequenced by tiling amplicons across the full genome, with amplicon schemes that changed over the pandemic as mutations in the viral genome interacted with primer binding sites. In combination with the disparate set of genome assembly workflows and lack of consistent quality control (QC) processes, the current genomes have many systematic errors that have evolved wit

SUBMITTER: Hunt M 

PROVIDER: S-EPMC11092452 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature