High-throughput crystallographic fragment screening of Zika virus NS3 Helicase.

ABSTRACT: The Zika virus (ZIKV), discovered in Africa in 1947, swiftly spread across continents, causing significant concern due to its recent association with microcephaly in newborns and Guillain-Barré syndrome in adults. Despite a decrease in prevalence, the potential for a resurgence remains, necessitating urgent therapeutic interventions. Like other flaviviruses, ZIKV presents promising drug targets within its replication machinery, notably the NS3 helicase (NS3^Hel) protein, which plays critical roles in viral replication. However, a lack of structural information impedes the development of specific inhibitors targeting NS3^Hel. Here we applied high-throughput crystallographic fragment screening on ZIKV NS3^Hel, which yielded structures that reveal 3D binding pose

SUBMITTER: Godoy AS 

PROVIDER: S-EPMC11092484 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature