Dementia Risk Scores, APOE, and risk of Alzheimer disease: one size does not fit all.

ABSTRACT:

Introduction

Evaluating the generalizability of dementia risk scores, primarily developed in non-Latinx White (NLW) participants, and interactions with genetic risk factors in diverse populations is crucial for addressing health disparities.

Methods

We analyzed the association of the Cardiovascular Risk Factors, Aging, and Incidence of Dementia (CAIDE) and modified CAIDE (mCAIDE) scores with dementia risk using logistic regression models stratified by race/ethnicity in NACC and ADNI, and assessed their interaction with APOE.

Results

Higher CAIDE scores were associated with an increased risk of dementia in Asian, Latinx, and NLW participants but not in Black participants. In contrast, higher mCAIDE scores were also associated with an increased risk of dementia i

SUBMITTER: Andrews SJ 

PROVIDER: S-EPMC11092714 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature