Alcohol use disorder and body mass index show genetic pleiotropy and shared neural associations.

ABSTRACT: Despite neurobiological overlap, alcohol use disorder (AUD) and body mass index (BMI) show minimal genetic correlation (r_g), possibly due to mixed directions of shared variants. We applied MiXeR to investigate shared genetic architecture between AUD and BMI, conjunctional false discovery rate (conjFDR) to detect shared loci and their directional effect, Local Analysis of (co)Variant Association (LAVA) for local r_g, Functional Mapping and Annotation (FUMA) to identify lead single nucleotide polymorphisms (SNPs), Genotype-Tissue Expression (GTEx) to examine tissue enrichment, and BrainXcan to assess associations with brain phenotypes. MiXeR indicated 82.2% polygenic overlap, despite a r_g of -.03. ConjFDR identified 132 shared lead SNPs, with 53 novel, showing

SUBMITTER: Malone SG 

PROVIDER: S-EPMC11092735 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature