3D MR Fingerprinting for Dynamic Contrast-Enhanced Imaging of Whole Mouse Brain.

ABSTRACT:

Purpose

Quantitative MRI enables direct quantification of contrast agent concentrations in contrast-enhanced scans. However, the lengthy scan times required by conventional methods are inadequate for tracking contrast agent transport dynamically in mouse brain. We developed a 3D MR fingerprinting (MRF) method for simultaneous T₁ and T₂ mapping across the whole mouse brain with 4.3-min temporal resolution.

Method

We designed a 3D MRF sequence with variable acquisition segment lengths and magnetization preparations on a 9.4T preclinical MRI scanner. Model-based reconstruction approaches were employed to improve the accuracy and speed of MRF acquisition. The method's accuracy for T₁ and T₂ measurements was validated in vitro, while it

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC11092875 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature