Tertiary Lymphoid Structures Gene Signature Predicts Prognosis and Immune Infiltration Analysis in Head and Neck Squamous Cell Carcinoma.

ABSTRACT:

Objectives

This study aims to assess the prognostic implications of gene signature of the tertiary lymphoid structures (TLSs) in head and neck squamous cell carcinoma (HNSCC) and scrutinize the influence of TLS on immune infiltration.

Methods

Patients with HNSCC from the Cancer Genome Atlas were categorized into high/low TLS signature groups based on the predetermined TLS signature threshold. The association of the TLS signature with the immune microenvironment, driver gene mutation status, and tumor mutational load was systematically analyzed. Validation was conducted using independent datasets (GSE41613 and GSE102349).

Results

Patients with a high TLS signature score exhibited better prognosis compared to those with a low TLS signature score. The group with a high T

SUBMITTER: Xing A 

PROVIDER: S-EPMC11092909 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature