Prevotella copri promotes vascular calcification via lipopolysaccharide through activation of NF-κB signaling pathway.

ABSTRACT: Emerging evidence indicates that alteration of gut microbiota plays an important role in chronic kidney disease (CKD)-related vascular calcification (VC). We aimed to investigate the specific gut microbiota and the underlying mechanism involved in CKD-VC. We identified an increased abundance of Prevotella copri (P. copri) in the feces of CKD rats (induced by using 5/6 nephrectomy followed by a high calcium and phosphate diet) with aortic calcification via amplicon sequencing of 16S rRNA genes. In patients with CKD, we further confirmed a positive correlation between abundance of P. copri and aortic calcification scores. Moreover, oral administration of live P. copri aggravated CKD-related VC and osteogenic differentiation of vascular smooth muscle cells in vi

SUBMITTER: Hao QY 

PROVIDER: S-EPMC11093026 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature