Spatio-temporal dynamics of the human small intestinal microbiome and its response to a synbiotic.

ABSTRACT: Although fecal microbiota composition is considered to preserve relevant and representative information for distal colonic content, it is evident that it does not represent microbial communities inhabiting the small intestine. Nevertheless, studies investigating the human small intestinal microbiome and its response to dietary intervention are still scarce. The current study investigated the spatio-temporal dynamics of the small intestinal microbiome within a day and over 20 days, as well as its responses to a 14-day synbiotic or placebo control supplementation in 20 healthy subjects. Microbial composition and metabolome of luminal content of duodenum, jejunum, proximal ileum and feces differed significantly from each other. Additionally, differences in microbiota composition along the sma

SUBMITTER: An R 

PROVIDER: S-EPMC11093041 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature