Roles of negative emotions and personality traits in psoriasis vulgaris: A mendelian randomization study.

ABSTRACT:

Background

Many studies have indicated that negative emotions and personality traits are related to psoriasis, though few have provided causal evidence.

Methods

Our analysis utilized 15 genome-wide association study datasets to identify instrumental variables associated with negative emotions, personality traits and psoriasis vulgaris. Two-sample Mendelian randomization was conducted to identify the causal associations of negative emotions and personality traits with psoriasis vulgaris. To mitigate bias from multiple tests, we adjusted p-values using the Benjamini-Hochberg method.

Results

Our study revealed causal links between negative emotions and psoriasis vulgaris, including depressed affect, worry too long, feeling hurt, guilty feelings, mood swings, unenthusiasm

SUBMITTER: Zhang M 

PROVIDER: S-EPMC11093070 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature