A multi-omics study to monitor senescence-associated secretory phenotypes of Alzheimer's disease.

ABSTRACT:

Objective

Alzheimer's disease (AD) is characterized by the progressive degeneration and damage of neurons in the brain. However, developing an accurate diagnostic assay using blood samples remains a challenge in clinic practice. The aim of this study was to explore senescence-associated secretory phenotypes (SASPs) in peripheral blood using mass spectrometry based multi-omics approach and to establish diagnostic assays for AD.

Methods

This retrospective study included 88 participants, consisting of 29 AD patients and 59 cognitively normal (CN) individuals. Plasma and serum samples were examined using high-resolution mass spectrometry to identify proteomic and metabolomic profiles. Receiver operating characteristic (ROC) analysis was employed to screen biomarkers with diagnos

SUBMITTER: Yang J 

PROVIDER: S-EPMC11093245 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature