Veillonella and Bacteroides are associated with gestational diabetes mellitus exposure and gut microbiota immaturity.

ABSTRACT:

Background

Dysbiosis during childhood impacts the configuration and maturation of the microbiota. The immaturity of the infant microbiota is linked with the development of inflammatory, allergic, and dysmetabolic diseases.

Aims

To identify taxonomic changes associated with age and GDM and classify the maturity of the intestinal microbiota of children of mothers with GDM and children without GDM (n-GDM).

Methods

Next-generation sequencing was used to analyze the V3-V4 region of 16S rRNA gene. QIIME2 and Picrust2 were used to determine the difference in the relative abundance of bacterial genera between the study groups and to predict the functional profile of the intestinal microbiota.

Results

According to age, the older GDM groups showed a lower alpha diversity

SUBMITTER: Valdez-Palomares F 

PROVIDER: S-EPMC11093295 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature