Transcriptomic characteristics according to tumor size and SUV_max in papillary thyroid cancer patients.

ABSTRACT: The SUV_max is a measure of FDG uptake and is related with tumor aggressiveness in thyroid cancer, however, its association with molecular pathways is unclear. Here, we investigated the relationship between SUV_max and gene expression profiles in 80 papillary thyroid cancer (PTC) patients. We conducted an analysis of DEGs and enriched pathways in relation to SUV_max and tumor size. SUV_max showed a positive correlation with tumor size and correlated with glucose metabolic process. The genes that indicate thyroid differentiation, such as SLC5A5 and TPO, were negatively correlated with SUV_max. Unsupervised analysis revealed that SUV_max positively correlated with DNA replication(r = 0.29, p = 0.009), pyrimidine metabolism(r = 0.50,

SUBMITTER: Ju SH 

PROVIDER: S-EPMC11094162 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature